A Study in Participants With End-Stage Renal Disease

Inclusion Criteria: * Have ESRD and are awaiting kidney transplant * Have a stable PRA score \>50% Exclusion Criteria: * Have had a tonsillectomy * Have a semi-permanent/tunneled catheter * Have had intravenous immunoglobulin (IVIg) in the past 6 months * Have had plasmapheresis in the past 6 months * Uncontrolled hypertension * Presence of clinically significant cardiac disease in the past 6 months * Malignancy in the past 5 years, with the exception of cervical, basal cell and squamous epithelial cell cancers * Have active or recent infection including herpes zoster or herpes simplex in the last 30 days * Have evidence or suspicion of active Tuberculosis (TB) * Have had major surgery in the past 2 months * Have had a serious infection with recovery in the past 3 months * Have Hepatitis B or C or have Human Immunodeficiency Virus (HIV)