This is a randomized, double blind, placebo controlled, parallel group, study in patients with chronic rhinosinusitis with or without nasal polyps. The objective is to test the clinical efficacy of long-term low dose oral doxycycline on wound healing quality after endoscopic sinus surgery.
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Endoscopic evaluation of quality and speed of wound healing
Timeframe: at 3 months after first drug intake
Recurrence of nasal polyps
Timeframe: at 3 months after first drug intake
Recurrence of nasal polyps
Timeframe: at 6 months after first drug intake