Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Inclusion Criteria: * Signed, and dated informed consent as defined by the Institutional Review Board. * Male and female patients older than 18 years of age undergoing primary elective hip, knee or shoulder arthroplasty. * Documented nasal carriage of MRSA. * If a female of childbearing potential the patient should agree to practice a reliable contraceptive method (e.g. birth control pills, condoms, or intrauterine device \[IUD\]) during treatment and for one month after receiving the study medication. Exclusion Criteria: * Concurrent urinary tract infection or colonization unless treated with evidence of microbiologic cure. * Evidence of active infection elsewhere other than urinary tract, unless treated with evidence of microbiologic cure documented by the infectious diseases service. * Patients undergoing elective secondary arthroplasty. * Concurrent open wounds * Pregnant and nursing women (if patient is still of childbearing potential, a negative serum pregnancy test will be confirmed). * History of allergy or contraindication to study drugs. * Weight \>150 kg or \<50kg * Patients with creatinine clearance (CLcr) \< 30ml/min (calculated using the Cockcroft-Gault equation using ideal body weight) * Severe neutropenia (absolute neutrophil count \<0.500x103 /µl). * Patients considered unlikely to comply with study procedures or to return for the scheduled post treatment evaluation. * Ongoing antibiotic therapy for active infection that is anticipated to continue until th…