Molecular Microbiology in Osteo-arthritis Infection (NCT01193803) | Clinical Trial Compass
CompletedNot Applicable
Molecular Microbiology in Osteo-arthritis Infection
France229 participantsStarted 2008-10
Plain-language summary
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated. Microbiological cultures are currently regarded as the reference for identification of pathogenic bacteria. However, the sensitivity of these cultures is very variable and depends both on the context in which clinical samples are taken, and on the pathogen involved. The rate of detection varies according to infection type: from 50 to 70% for infectious spondylodiscitis, 65 to 95% for prosthetic joint infections, 50% for gonococcal arthritis and 90% for non-gonococcal arthritis. The aim of the study is to evaluate the diagnostic performances of microbiological cultures and molecular methods in case of osteoarticular infections. The gold standard will be established by an expert group of osteoarticular infection (composed by a bacteriologist, a radiologist, a surgeon, an anatomy-pathologist and a rheumatologist), which established the final diagnosis of infected or not infected patients.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patient are more than 18 years old
* Patient who do not declined to have his medical records reviewed for research
Spondylodiscitis (S) group:
* Patients suspected of Discitis and/or Vertebral Osteomyelitis is defined by the need of spinal biopsy in infectious context. Spinal biopsies will be justified by one or more clinical or imaging findings:
* Clinical presentation
* Spinal pain unrelieved by rest
* Localized tenderness, Neurological deficits or limited range of motion
* Fever \> 38°C
* Imaging findings (plain radiographs, MRI or CT):
* Erosions of end plates on adjacent vertebral bodies
* Decreased height of the intervertebral disk
* Presence of a nonvascularized zone suggesting presence of pus or necroses in intervertebral, epidural space or in paraspinal soft-tissues
Prosthetic Joint Infection (PJI) Group
Patients suspected of Prosthetic Joint Infection were defined by the need of surgical revision for diagnostic or therapeutic aiming in infectious context. This revision will be justified by one or more clinical, biological or imaging findings:
Clinical presentation
* Persistent joint pain
* Fever \> 38°C
* Erythematous, swollen, fluctuant, and/or tender surgical wound
* Wound dehiscence
* Limited range of joint motion
Biological findings
* CRP \> 10 mg/l
* Synovial leukocytes count \> 1500/mm3 and polymorphonuclear leukocytes \> 65%
Imaging findings
* Prosthesis loosening: Periprosthetic osteolysis, progressive peri-prosthetic edgi…
What they're measuring
1
Prosthetic Joint Infections, Vertebral Osteomyelitis and Septic arthritis: Frequency of detection with classical bacteriological methods and molecular methods