Evaluation of an Acellular Osteochondral Graft for Cartilage LEsions Pilot Trial

Inclusion Criteria: * 21 years old and skeletally mature * KOOS Pain subscale score is less than 65 (i.e. moderate pain) * KOOS Activities of Daily Living score is less than 70 (i.e. moderate functional limitations) * ICRS grade 3 or 4 cartilage lesion on the medial femoral condyle, lateral femoral condyle or trochlea measuring less than or equal to 15mm in diameter * Stable meniscus with greater than 50% remaining bilaterally * Mental capacity and willingness to comply with the post-operative rehabilitation plan and follow-up evaluations * Written informed consent Exclusion Criteria: * Body mass index greater than 35 * Contraindication for MRI * Previous microfracture, autograft implantation, allograft implantation or autologous chondrocyte implantation procedure on the damaged cartilage surface * Knee ligament surgery within the past 6 months * Clinically significant knee malalignment * Osteoarthritis in the knee * Multiple cartilage lesions * Inflammatory arthropathy (i.e. rheumatoid arthritis, systemic lupus or active gout) * Active infection in either lower limb * Hyaluronic acid or cortisone injections within the past 3 months * History of substance abuse * Current participation in a study of an investigational product for a similar purpose * Active litigation for the knee injury