Assessment of Children With Tic Onset in the Past 6 Months (NCT01177774) | Clinical Trial Compass
CompletedNot Applicable
Assessment of Children With Tic Onset in the Past 6 Months
United States99 participantsStarted 2010-08
Plain-language summary
The purpose of this research is to study why most children who have tics never develop Tourette syndrome but some do. In other words, we aim to find features that may predict whose tics will go away and whose tics will continue or worsen, in children ages 5 through 10 years whose first tic occurred within the past 9 months.
Who can participate
Age range5 Years – 10 Years
SexALL
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\*\* All subjects \*\*
Inclusion Criteria:
* Age 5-10
* Informed consent from a parent and assent from the child.
* New Tics Group \*\*
Inclusion Criteria:
* tics now, but developed them only in the past 9 months.
Exclusion criteria: secondary tics, another neurological disorder (not counting migraine), structural brain disease, severe systemic illness, nonproficiency in the English language, and psychiatric illness including mental retardation, autism, substance dependence, current substance abuse, primary psychotic illness, bipolar disorder and current major depression. Psychoactive medications are allowed if their dose has not changed in the past month.
\*\* Existing TS/CTD control group \*\*
Inclusion criteria:
* children who meet DSM-5 criteria for Tourette's Disorder or Persistent Tic Disorder at enrollment
* matched to children from the New Tics group on age (within 1 year), sex, handedness, and ADHD status.
Exclusion criteria: same as for the New Tics group.
\*\* Tic-free controls \*\*
Inclusion criteria: tic-free children matched to children from the New Tics group on age (within 1 year), sex, handedness, and ADHD status.
Exclusion criteria: current or past tic disorder in the subject or a first-degree relative, plus the exclusions listed for the New Tics group.
What they're measuring
1
DSM-5 diagnosis of a chronic tic disorder at 12 months
Timeframe: 1 year after the onset of tics (6-12 months after the first study visit)