Teriparatide for Postsurgical Hypoparathyroidism (NCT01171690) | Clinical Trial Compass
TerminatedPhase 2
Teriparatide for Postsurgical Hypoparathyroidism
Stopped: Funding problems
United States5 participantsStarted 2010-11
Plain-language summary
This study evaluated the effects of teriparatide (Forteo) on low calcium levels in the setting of thyroid surgery associated with low parathyroid hormone. The hypothesis was that teriparatide ( Forteo) would shorten the length of hospitalization post thyroidectomy in patients with symptomatic hypoparathyroidism.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Patients post bilateral thyroid bed surgery (cancer, Graves disease, multinodular goiter)
* Symptomatic hypocalcemia
* Total calcium \< 8 mg/dL persisting after 24 hours of therapy with calcitriol (minimum 0.25 mcg twice a day) and calcium supplementation (minimum 1.5 grams of elemental calcium per day)
* Parathyroid hormone (PTH) level below low end of normal range
Exclusion criteria (all subjects):
* Renal failure
* Any prior parathyroid pathology
* Pre-existing hypercalcemia
* Metabolic bone diseases other than osteoporosis
* Pagets disease
Exclusion criteria (active treatment subjects only):
* Ongoing therapy with Forteo for osteoporosis
* Active non-thyroidal malignancy or suspicion of residual thyroid malignancy
* History of skeletal malignancies, primary or metastatic
* Pregnancy
* Active or recent urolithiasis
* Digitalis therapy
* Patients at increased baseline risk for osteosarcoma, i.e., family history of osteosarcoma or prior radiation therapy involving the skeleton
* Pediatric populations
* Unexplained elevations of alkaline phosphatase
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.