Efficacy and Safety Study of Nexagon for Persistent Corneal Epithelial Defects

Inclusion Criteria: * Male and female subjects aged 18 years and over. * Female subjects must be a) postmenopausal, b) surgically sterilized, c) practicing abstinence, or d) using a hormonal contraceptive, intrauterine device, diaphragm with spermicide, or condom with spermicide for the duration of the study. * Subjects who are able to attend all follow-up visits and who are able to comply with all study procedures. * Subjects who are willing and able to give written informed consent to take part in the study. * Subjects with a PED, defined as follows: "a corneal epithelial defect persisting for at least 14 days and not longer than 28 days." * In the Investigator's opinion, the defect is persistent i.e., the defect has not shown improvement despite conventional treatment such as tear supplements and bandage contact lenses. * The original defect to the cornea must have resulted from corneal epithelial debridement during diabetic vitrectomy surgery, HSV keratitis, HZV keratitis, corneal burns, post-PRK, or post-corneal transplant surgery. Exclusion Criteria: * Use of concomitant ocular medications in the screening period that are not specified in standardized PED treatment regimen * Likely to require the use of concomitant ocular medications that are not specified in the standardized PED treatment regime during the study follow-up period * Decrease or increase in the PED by more than 50% during the screening period. * Have an active eyelid or ocular infectious process of any…