Donor Simvastatin Treatment in Organ Transplantation

Inclusion criteria for a donor: * Heart transplant donor * Age 18-60 years * Previously healthy * No cholesterol medication * Normal ECHO with LVEF \>45%, normal right ventricle and normal coronary angiography * PiO2/FiO2 \> 40kPA, normal chest radiograph and normal bronchoscopy in lung donors Exclusion Criteria for the heart/lung donor: * Severe left ventricular hypertrophy \> 14 mm * High dose of inotropes (dopamine or dobutamine \> 20ug/kg/min or norepinephrine \>0.2 ug/kg/min) at the time of procurement * Donor outside of the study country Finland Inclusion criteria for a transplant recipient: * Age between 18-70 for heart transplant recipients * Male or female * Listed for heart, lung, kidney, or liver transplantation Exclusive Criteria for the recipient * systemic sepsis * a positive cross match