This phase I clinical trial is studying the side effects and best dose of RO4929097 when given together with capecitabine in treating patients with refractory solid tumors. RO4929097 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving RO4929097 together with chemotherapy may kill more tumor cells.
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MTD of RO4929097 and capecitabine, defined as that dose level at which less than one-third of patients experience a dose-limiting toxicity (DLT) graded according to NCI CTCAE version 4.0 (Part 1)
Timeframe: Up to 21 days
Incidence of adverse events graded according to NCI CTCAE version 4.0 (Part 1)
Timeframe: Up to 30 days after completion of study treatment
Incidence of adverse events graded according to NCI CTCAE version 4.0 (Parts 2a and 2b)
Timeframe: Up to 24 months