VA-006 Vaccinia Vaccine (ACAM2000) for the Production of VIGIV

Inclusion Criteria: * Signed written informed consent. * Age 18 - 65 years. * Normal and healthy as determined by medical history, physical exam, vital signs and clinical laboratory tests at screening visit. * Subject must meet all required subject suitability criteria that pertain to normal Source Plasma donors. * Subject must have been previously immunized for smallpox, at ≥1 year prior to commencement of screening assessments for the VA-006 trial, and vaccination history must be confirmed by oral or written history AND the presence of a visible pathognomonic smallpox vaccination scar. * Female subjects of childbearing potential must use at least one of the following means of birth control documented by a physician's letter: * Surgical sterilization * Hormonal (oral/injectable/implant) for at least 30 days prior to vaccination * Intrauterine device (IUD) inserted at least 7 days prior to vaccination. * Female subjects who are not using one of the methods of birth control listed above must be documented as postmenopausal, which is defined as not having a menstrual period for longer than 12 months and having a serum follicle-stimulating hormone (FSH) level ≥ 40 mIU/mL. Exclusion Criteria: * History of severe adverse event(s) from previous participation in the VA-001 or VA-005 trials or any other smallpox vaccination program/study. * Subject, household contact, or other close/intimate contact: * with eczema, history of eczema, exfoliative skin conditions, wounds, …