Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers

Inclusion Criteria: * Healthy volunteer for medical history and physical examination findings * 18 years, \<40 years * Written informed consent is given * No clinically relevant changes in laboratory parameters * Inconspicuous current ECG * taking medication under a different drug trial within the last 30 days Exclusion Criteria: * concomitant medication at study days or a week before * allergies or known hypersensitivity reactions to furosemide or aminohippurate sodium * decreased creatinine clearance by Cockcroft-Gault (\<100 ml / min) * current drug abuses * opiate addiction within the last 10 years * smoking within the last year * pregnancy and 6 months postpartum, lactation * deprivation of legal capacity * Cooperation inability