Progesterone vs Clobetasol Propionate in Vulvar Lichen Sclerosus

Inclusion Criteria: * Signed informed consent * Consent to biopsy at start and end of therapy * Suspicion of Lichen sclerosus * Pre-menopausal * Age ≥18 years Exclusion Criteria * Prior surgery at the vulva, with exception of episiotomy * Pregnancy * Signs of infection with human papilloma virus at the vulva * Vulvar intraepithelial neoplasia (VIN) * Known generalised autoimmune disease * Lichen sclerosus since childhood * Prior therapy with topic clobetasol propionate or other immunosuppressives (tacrolimus or pimecrolimus) at the vulva * Atopic diathesis and/or contact allergy * Systemic immunosuppressive therapy * Genital infection within the last four weeks (eg., condyloma acuminata, candidiasis)