Cortical Plasticity Assessment in Athletes With a History of Concussion (NCT01112761) | Clinical Trial Compass
TerminatedNot Applicable
Cortical Plasticity Assessment in Athletes With a History of Concussion
Stopped: Lack of resources to run the trial
United States1 participantsStarted 2010-04
Plain-language summary
The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability.
Single and paired transcranial magnetic stimulation (TMS) can be used as reliable neurophysiological marker of motor cortex reorganization in athletes with concussions.
This study also aims to determine whether modulation of cortical activity by a powerful technique of noninvasive brain stimulation (tDCS) results in a different cortical response as compared with sham tDCS.
Who can participate
Age range18 Years – 30 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Student-athletes at risk for traumatic brain injury (collegiate football, ice hockey)
* Age between 18 and 30 yr.
* Concussion as defined by the American Academy of Neurology: trauma-induced alteration in mental status that may or may not involve loss of consciousness (confusion and amnesia are the hallmarks of concussion)
* Concussion that occurred \> 6 months
* All head injuries classified as minor with a Glasgow Coma Scale of 13 to 15 at the time of the trauma
* Participants are cleared for full sport participation based upon neurological and neuropsychological (NS) assessments Classified as symptomatic based on Post-concussion Symptom List
Exclusion Criteria:
* Previous significant neurological history
* Use of tricyclic anti-depressants such as amitriptyline, nortriptyline and imipramine within the past six months.
* Use of anticonvulsants such as carbamazepine, phenytoin, valproic acid and gabapentin within the past six months
* History of seizures, depression or PTSD
* Presence of post-concussion symptoms such as complaints of loss of concentration, dizziness, fatigue, headache, irritability, visual disturbances, and light sensitivity.
* Contraindications to single pulse TMS (TMS will be used to measure cortical excitability) such as metal head implants
* history of seizures
* unexplained loss of consciousness
* metal in the head
* frequent or severe headaches or neck pain
* implanted brain medical devices.
* Contraindications to tDCS:
* metal …
What they're measuring
1
Cortical excitability and cortical plasticity assessment