Mucosal Response in Immunocompromised Host

HEALTHY VOLUNTEERS Inclusion criteria: * Above 18 years of age * Informed consent Exclusion Criteria: * History of an auto-immune disease (SLE, ANCA associated vasculitis, Goodpasture, Henoch Schonlein, cryoglobulinemia, secondary vasculitis, polyarteritis nodosa and immunodeficiency disorders like IgA deficiency) * Chronic infection * Past vaccination with Dukoral or another cholera or ETEC vaccine * History of infection with Vibrio cholerae * Episode of diarrhoea in the 6 months prior to inclusion * Allergy to vaccine-specific components * History of a severe allergic reaction to any vaccine * Treatment with blood products in the 3 months prior to inclusion * Current pregnancy or breastfeeding * Premenopausal women not willing to use contraceptives during the first 60 days after vaccination * Use of any immunosuppressive drug RENAL TRANSPLANT RECIPIENTS Inclusion Criteria: * Above 18 years of age * Creatinin clearance ≥ 40 ml/min measured in the 6 months prior to inclusion * Stable renal function for 1 year prior to inclusion * Stable immunosuppressive regimen of a CNI, MMF or mTORi combined with prednisolone for at least 3 months prior to inclusion * Informed Consent Exclusion Criteria: * History of an auto-immune disease (SLE, ANCA associated vasculitis, Goodpasture, Henoch Schonlein, cryoglobulinemia, secondary vasculitis, polyarteritis nodosa and immunodeficiency disorders like IgA deficiency) * Chronic infection * Treatment for rejection of the transplant in t…