Dosing Regimen of Eculizumab Added to Conventional Treatment in Positive Crossmatch Deceased Donor Kidney Transplant

Inclusion Criteria: * 18 years of age * Has end stage renal disease (ESRD) and is to receive a kidney transplant from a deceased donor (DD) to whom he/she has a positive T or B cell crossmatch \>200 at the time of transplant and DSA demonstrated by solid phase assays. * Willing to comply with the protocol * Females of child-bearing potential must have a negative pregnancy test (serum β-HCG) and sexually active females must agree to use a reliable and medically approved method of contraception * Willing and able to give written informed consent * Vaccinated against Neisseria meningitides (quadrivalent vaccine), Pneumococcus and H. influenzae at least two weeks prior to beginning desensitization Exclusion Criteria: * Unstable cardiovascular condition * Previous splenectomy * Active bacterial or other infection which is clinically significant in the opinion of the investigator * Known or suspected hereditary complement deficiency * Participation in any other investigational drug study or was exposed to an investigational drug or device within 30 days of randomization * Pregnant, breast-feeding, or intending to conceive during the course of the study, including a one month follow-up period after drug discontinuation * Known hypersensitivity to the treatment drug or any of its excipients * History of illicit drug use or alcohol abuse within the previous year * History of meningococcal disease * Medical condition that, in the opinion of the investigator, might interfere with the…