A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy … (NCT01097577) | Clinical Trial Compass
CompletedNot Applicable
A Comparison of Pregabalin (Lyrica®) to Placebo in Pain Relief After Photorefractive Keratectomy (PRK) Surgery
United States130 participantsStarted 2010-03
Plain-language summary
The purpose of this study is to compare the efficacy of pregabalin to placebo for postoperative pain control after photorefractive keratectomy.
Who can participate
Age range21 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy ocular status
* Stable preoperative refractive anisometropia
* Consented to the PRK surgical procedure
Exclusion Criteria:
* Pregnant or breastfeeding
* Diagnosed with autoimmune disease or diabetes
* Patients with a known adverse reaction or hypersensitivity to gabapentin or pregabalin
* Patients only desiring PRK on one eye
* Patients with history of drug use/abuse/addiction
* Patients who are on chronic pain medications
* Patients currently taking anti-epileptic, antidepressant and/or anti-psychotic medications
* Patients with a history of suicidality
* Patients with chronic renal insufficiency (defined as estimated creatinine clearance less than 30ml/min or Scr ≥ 2.0) 10) Patients who have experienced angioedema, or have heart failure