A Study of Plazomicin Compared With Levofloxacin for the Treatment of Complicated Urinary Tract Infection (cUTI) and Acute Pyelonephritis (AP)

Key Inclusion Criteria: * Documented or suspected cUTI/AP with clinical signs and symptoms * Normal kidney function defined as creatinine clearance (CLcr) of ≥60mL/min using Cockcroft-Gault formula Key Exclusion Criteria: * Acute bacterial prostatis, orchitis, epididymitis, or chronic bacterial prostatis * Gross heanaturia requiring intervention other than study drug * Urinary tract surgery within 7 days of randomization or during the study period * A known nonrenal source of infection diagnosed within 7 days of randomization * A corrected QT interval \> 440 msec * History of hearing loss with onset before the age of 40 years, sensorineural hearing loss, or family history of hearing loss * Pregnant or breastfeeding women