Marinol in Trichotillomania or Obsessive Compulsive Disorder (NCT01093976) | Clinical Trial Compass
CompletedPhase 2
Marinol in Trichotillomania or Obsessive Compulsive Disorder
United States14 participantsStarted 2010-04
Plain-language summary
The goal of the proposed study is to evaluate the efficacy and safety of dronabinol in individuals with obsessive-compulsive disorder (OCD) or the obsessive-compulsive spectrum disorders, trichotillomania (TTM) or pathological skin picking (PSP). Fifteen patients with OCD, TTM, or PSP will receive 12 weeks of open-label treatment with dronabinol. The hypothesis to be tested is that dronabinol will be effective and well tolerated in patients with these disorders. The proposed study will provide needed data on the treatment of a disabling disorder that currently lacks a clearly effective treatment.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Age 18-65 years
✓. Obsessive-compulsive disorder (OCD), Trichotillomania (TTM), or Pathological Skin Picking (PSP) as the primary psychiatric diagnosis
✓. (If OCD) - Subject reports ≥two failed treatments using selective serotonin reuptake inhibitors (SSRIs) for their OCD
✓. Women's participation required negative results on a beta-human chorionic gonadotropin pregnancy test and stable use of a medically accepted form of contraception.
✓. Signed informed consent before entry into the study.
Exclusion criteria
✕. Unstable medical illness or clinically significant abnormalities on laboratory tests or physical examination at screening visit
✕. Current pregnancy or lactation, or inadequate contraception in women of childbearing potential
✕. A need for medication other than dronabinol with possible psychotropic effects
✕. History of hypersensitivity to any cannabinoid or sesame oil
What they're measuring
1
Massachusetts General Hospital Hairpulling Scale (MGH-HPS) Total Score
Timeframe: Subjects were followed for their duration of participation in the study (12-weeks)