CompletedNot Applicable

Changes in Specific Immunoglobulin and Blood Basophil Activity During Subcutaneous Immunotherapy in Allergic Rhinitis

30 participantsStarted 2010-02

Plain-language summary

The trial is randomized prospective study to examine the effects of subcutaneous immunotherapy on the adaptive immune system. The trial includes 30 participants randomized to treatment or control group. The effect measures are changes in the basophil activity and biology as well as changes in plasma cells during and after treatment. Clinical outcome is assessed by QoL questionnaires and clinical testing. Hypotheses: * changes in plasma cells correlate to changes in immunoglobulins and effector cell responses * the reduction of inflammation due to SCIT has influence on the effector cell responses * changes in paraclinical measurements can be related to clinical findings

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * rhinoconjunctivitis due to grass pollen allergy * positive skin prick test and nasal allergen challenge test to grass pollen extract Exclusion Criteria: * severe comorbidity, severe asthma, pregnancy

What they're measuring

a significant decrease in basophil activity during and after treatment

Timeframe: every 3 weeks for 3 months, then 3 monthly for 3 years

Trial details

NCT IDNCT01085526

SponsorAarhus University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-07

View on ClinicalTrials.gov More Allergic Rhinoconjunctivitis trials