Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites

Inclusion Criteria: * • Healthy 18 to 45 years old man or non-pregnant women. * To have the capacity to sign an informed consent in a free and voluntary way. * Have an acceptable understanding of the clinical trial through the approval of a questionnaire regarding the information given in the consent process. * Obligatory use of adequate contra-conceptive method from beginning of recruitment and screening time up to three months after last immunization * Do not have chronic or acute diseases. These conditions will be determined by clinical history, physical exam and laboratory tests. * To accept not traveling to malaria endemic areas during the clinical trial should * To have telephone at home or mobile phone that permit permanent contact for follow up * He (she) manifest that is willing to participated during both steps of the clinical trial. Exclusion Criteria: * Volunteers with less than 18 old year or more than 45 old years. * Pregnant and suckling women will be excluded. Pregnancy will be determined both by interview, and by serum B-subunit chorionic gonadotrophin testing. * History of moderate or severe insect, or food allergies. * G-6PD deficiency or any Hb genetic defect (for example; sickle cell disease) * Previous malaria infection demonstrated by think smear, PCR or specific antimalarial antibodies. * If the subject has previously participated in a malarial vaccine trial. * Clinical record of allergies to drug or insect bites. * Symptoms, signs or…