Trichuris Suis Ova in Peanut and Tree Nut Allergy

Inclusion Criteria: * 18 to 64 years old * Positive skin-prick test to peanut or tree nut and a history of significant clinical symptoms within 60 minutes after the ingestion of peanuts or tree nuts. * Peanut or tree nut allergy of mild to moderate grade based on the presence of localized or generalized erythema/urticaria/angioedema/oral pruritis, gastrointestinal symptoms, rhinoconjunctivitis, or mild laryngeal edema (voice change/tightening of throat/mild asthma), and the absence of symptoms/signs of severity (marked dyspnea, hypoxia, cyanosis, hypotension, confusion, incontinence, collapse or loss of consciousness) * Otherwise in good health * Ability to provide written informed consent Exclusion Criteria: * History of severe anaphylaxis to peanut as defined by hypoxia, hypotension, or neurological compromise (cyanosis or SpO2 \< 92% at any stage, confusion, collapse, loss of consciousness, or incontinence) * Poor control of atopic dermatitis or current flare requiring an increase in atopic dermatitis medication * Inability to discontinue antihistaminic for skin testing * Severe persistent asthma as defined by the NHLBI criteria * Asthma that requires oral steroids * Asthma that has been controlled for less than 1 year * FEV1\<80% at the screening visit or immediately before the 1st administration of TSO * Currently being treated with greater than medium daily doses of inhaled corticosteroids, as defined by the NHLBI guidelines * Abnormal blood cell count * Abnormal ren…