Multiple Doses and Regimens of Cabozantinib in Subjects With Grade IV Astrocytic Tumors in First or Second Relapse

Inclusion Criteria: * The subject has histologically confirmed diagnosis at any time of grade IV astrocytic tumor as determined by the investigator. Tumor samples will be required for pathology review. * The subject has received prior standard radiation for any grade astrocytic tumor. * The subject has received prior temozolomide (Temodar) therapy * The subject has had one or two progressions as grade IV astrocytic tumor from any grade, as determined by investigator * The subject must have a qualifying brain MRI scan within a specific timeframe prior to start of study treatment * For subjects with recent tumor resection or biopsy, starting on study must occur a specified amount of time after the surgery and the subject must have recovered from the effects of surgery * The subject has a Karnofsky Performance Status ≥ 70% and has the ability to swallow whole capsules * The subject is capable of understanding the informed consent and has signed the informed consent document * The subject has adequate organ and marrow function * Sexually active subjects (male and female) must agree to use medically accepted methods of contraception during the course of the study and for 6 months following discontinuation of study treatment * The subject has had no other diagnosis of malignancy (certain exceptions apply) * Female subjects of childbearing potential must have a negative pregnancy test at screening Exclusion Criteria: * The subject has received certain prior anticancer therapies w…