Reversal of Obese/Diabetic Cardiomyopathy After Gastric Bypass Surgery

Inclusion Criteria: * All subjects will have type 2 diabetes or be at risk for type 2 diabetes and have a BMI\>30kg/m2. * Subjects must be between the ages of 35 and 70 years, in order to limit the confounding affect of age on our endpoints. * 23 Subjects must also meet the following definition of diastolic dysfunction: * 1\) meet Framingham criteria for heart failure (see Appendix), * 2\) have an ejection fraction \>45% based on the rest portion of the screening echocardiography, * 24 To determine if potential subjects meet these criteria, they will * 1\) be interviewed, * 2\) their clinical charts reviewed, by the research study coordinator and/or the PI, and * 3\) undergo a history and physical by the PI (Study Day 2) and undergo screening studies. Exclusion Criteria: * Subjects who are \<35 or \>70 years, * current smokers, not obese, * unstable, * not able to lie flat for the imaging studies, * not ambulatory, * unable to give informed consent, * pregnant, lactating will be excluded. * Those who have a condition that may masquerade as diastolic heart failure (e.g. constrictive pericarditis) will be excluded based on the screening echocardiogram; * those who have atrial flutter or fibrillation, * evidence of other major systemic diseases (e.g., cancer), * an ejection fraction \<45%, \>class I hypertension or who are taking more than 1 medication (other than a diuretic) for hypertension will be excluded. * We will not exclude patients with sleep apnea becaus…