This study is to test escalating doses of intraperitoneal (IP) oxaliplatin in conjunction with systemic bevacizumab and capecitabine in patients with Peritoneal Carcinomatosis (PC) from either appendiceal or colorectal adenocarcinoma that have been adequately cytoreduced and have undergone a peritoneal scan demonstrating patency of at least one of the intraperitoneal ports that were placed at the time of debulking.
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To determine the maximum tolerated dose of IP oxaliplatin with systemic intravenous bevacizumab and oral capecitabine after surgical debulking and peritoneal scan documenting functional of intraperitoneal ports in patients with peritoneal carcinomatosis
Timeframe: Completion of enrollment (approximately 8 years)
Assess the safety and tolerability of IP oxaliplatin and intravenous (i.v.) bevacizumab and oral capecitabine after surgical debulking and functional intraperitoneal ports in patients with peritoneal carcinomatosis of appendiceal or colorectal etiology
Timeframe: 30 days after completion of treatment (estimated to be 22 weeks)
Progression rate
Timeframe: Through 4-12 weeks post-treatment (estimated to be 30 weeks)
Progression-free survival (PFS)
Timeframe: Through completion of follow-up (estimated to be 5 years)
Overall survival
Timeframe: Through completion of follow-up (estimated to be 5 years)