Minimal Stimulation Protocol Using Aromek(Letrozole) and Follitrope(recFSH) Combined With INVOCel… (NCT01058252) | Clinical Trial Compass
UnknownNot Applicable
Minimal Stimulation Protocol Using Aromek(Letrozole) and Follitrope(recFSH) Combined With INVOCell-Low Cost IVF
Pakistan30 participantsStarted 2021-05
Plain-language summary
The purpose of this study to evaluate a low cost minimal stimulation protocol combined with Intravaginal Culturing, to make IVF affordable and available across the large infertile/subfertile population
Who can participate
Age range20 Years – 37 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Tubal factor without Hydrosalpinx
* Unexplained infertility with unsuccessful attempts in achieving pregnancy through timed intercourse or IUI
* Boarder line male factor infertility
* Sperm DNA Fragmentation \< 30%
* Normal Uterine Cavity
* Normal baseline ultrasound with adequate number of primary follicles present
* Normal FSH and E2 on Day 3
* Age of the female is \< 35 years old
Exclusion Criteria:
* If previous IVF or INVO attempts resulted in failed fertilisation
* Male partner who has difficulty in producing semen sample
* Very low sperm count, very low percentage of sperm motility and morphology
* Sperm DNA Fragmentation \> 30%
* Age of female patient \> 37 years
* Borderline or elevated E2 or FSH on day 3 or failed CCCT or low blood inhibin levels
* Poor ovarian response
* Hydrosalpinx
* Anatomic difficulties in reaching ovaries for oocyte retrieval
* Cervical stenosis, making embryo transfer difficult
* Uterine abnormalities or deformities
* Obesity
What they're measuring
1
Number of Follicles >18 mm on the day of HCG; Number of Oocytes aspirated; Fertilisation Rate