A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni

Inclusion Criteria: * Aged between 6 and 15 years old * Study participants appear healthy at enrollment, as assessed by the study clinician * Suffering from S. mansoni infection, excreting eggs in stool * Residing in Uyoma area, near Lake Victoria * Able to receive oral treatment * Parent/legal guardian gives informed written consent for the child to participate in the study * Child assent to participate in study Exclusion Criteria: * Weighing more than 50 kg * Pregnant or lactating at the time of the study * Presence of infection with Plasmodium falciparum or other Plasmodium spp. * Presence of severe illness, such as cerebral cysticercosis * Signs of severe malnutrition (defined as children with weight/height ratio below 3 standard deviations or below 70% of the median of the WHO standardized reference values, or still with symmetrical oedema affecting both feet) * Hypersensitivity to As, sulfonamides or PZQ. * Use of another anti-malaria or anti-schistosomal drug during the study, or within 28 days before the administration of treatment. * Previous participation in this study.