Phase 1/2a Trial of Pf GAP p52-/p36- Sporozoite Malaria Vaccine

Inclusion Criteria: * A male or non-pregnant, non-lactating female 18 to 50 years of age (inclusive) at the time of enrollment * Free of significant health problems as established by medical history, laboratory assessment and clinical examination before entering into the study * Volunteers must have low cardiac risk factors according to the NHANES I criteria and a non-significant electrocardiogram (EKG) as determined by a expert consultant cardiologist * Available to participate for duration of study * Reproductive status: a female participant must: * not be of reproductive potential: i.e. be surgically, medically or physiologically sterile, or * if engages in sexual activity that could lead to pregnancy: * agrees to consistently use contraception until 2 months after the last protocol visit. Contraception is defined as using 1 of the following methods: * condoms (male or female) with or without a spermicide * diaphragm or cervical cap with spermicide * intrauterine device (IUD) * hormonal contraception * If the volunteer indicates he/she is active duty military (on the DCT sign-in page and intake form), approval from their supervisor through the Division Director using the Statement of Supervisor's Approval Form must be signed and on file prior to receipt of any test product * Written informed consent must be obtained from the subject before screening procedures * Prior to entry into this study, subjects must score at least 80% correct on a 10- question multiple-choice quiz…