Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy

Inclusion Criteria: * Age ≤ 80 years * Presence of ostial renal artery stenosis ≥ 70% (determined by Duplex Doppler ultrasonography and confirmed by Magnetic Resonance valuated by at least two experienced operators) * Serum creatinine ≤ 3 mg/dl and/or creatinine clearance (Modification of Diet in Renal Disease, MDRD formula)≥ 30 ml/min, defined as stage 3 or greater CKD based on National Kidney Foundation classification * Longitudinal ultrasonographic diameter of the stenotic kidney ≥ 8 cm * Blood pressure values ≤ 150/90 mmHg with the use of less than four hypotensives drugs Exclusion Criteria: * Age \> 80 years * Other well-known nephropathy cause of renal failure * Duplex doppler ultrasonography Resistive Index values \>0.8 * Total occlusion of renal artery lumen * Occurrence of cerebral or cardiac vascular diseases in the 6 months before the enrolment in the study * Malignancy with a life expectation less than one year * Previous documented cholesterol thrombo embolization episodes (clinically, bioptically or instrumentally) * Liver failure * Cardiac failure (NYHA IV class) or instable angina * Well-known intolerance or contraindications to the use of iodinated contrast media, to statins or to anti platelets drugs * Previous renal angioplasty * Pregnancy