Efficacy Safety Study of Flu Vaccine in Immunodepression Patients

Inclusion criteria : * informed consent signed * Age between 18 to 64 * Patient suffering from chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or indeterminate colitis) * For patients receiving at least one immunosuppressive or anti-TNF therapy: treatment introduced for at least 3 months * Patient willing to participate in the study throughout its duration and acceptance procedures related to the study (blood samples, self questionnaires, nasal swab and telephone follow-up) Exclusion criteria : * Patient treated by corticosteroid alone without immunosuppressive or anti-TNF * For women, being pregnant or positive pregnancy test * Known allergy to any component of the study vaccine or a history of hypersensitivity reaction to influenza vaccination * Fever (at least 37.5°C measured orally) or acute infection in the week prior to vaccination * Received influenza vaccination in the 6 months preceding enrollment * Known history of progressive neuropathy or Guillain-Barre * Known infection with HIV and/or HBV (Ag-HBs positive) and/or HCV * Other causes of severe immune deficiency * Cellular therapy, immunoglobulin infusions, of blood products or monoclonal antibodies (except anti-TNF) in the 3 months prior to vaccination * Patient deprived of freedom by an administrative or court order * Patient non affiliated to a health social security system