A Study Assessing Change in Sense of Smell After Rasagiline Use in Parkinson's Patients

Inclusion Criteria: * Men and women with Parkinson's Disease (PD), defined as the presence of at least two of the cardinal signs of PD (bradykinesia, resting tremor, rigidity) without other identifiable cause of parkinsonism or signs of atypical parkinsonism * Functional hyposmia or anosmia, as defined by UPSIT scores less than the 25th percentile for age- and gender-matched norms * Have been on stable dose of PD medications for at least 30 days * Age \< or = 90 years * Willing and able to give informed consent * Women of child-bearing potential may participate provided they are willing to use adequate contraceptive methods during the duration of the study. Women of childbearing potential must have a negative pregnancy test at the screening visit and be non-lactating. Exclusion Criteria: * Prior use of an MAO inhibitor, including selegiline or rasagiline within the last 12 months * Presence of other conditions that in the investigator's opinion may significantly cause olfactory impairment, including prior head trauma, nasal surgery, nasal inflammation causing concurrent congestion or polyps, nasal or sinus infection, prior intranasal zinc salt (Zicam) use, history of smoking within the past year * Presence of dementia or significant cognitive impairment with Mini-Mental State Examination (MMSE) \< 24 * Present of a medical or surgical condition which in the opinion of the investigator would preclude participation in and completion of study procedures * Use of any experimen…