A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies

Inclusion Criteria: * Patients with histologically/cytologically confirmed advanced solid tumors with FGFR1 or FGFR2 amplification or FGFR3 mutation, for which no further effective standard anticancer treatment exists * Adequate bone marrow function * Adequate hepatic and renal function * Adequate cardiovascular function * Contraception. * For women: Must be surgically sterile, post-menopausal, or compliant with a medically approved contraceptive regimen during and for 3 months after the treatment period; must have a negative serum or urine pregnancy test and must not be nursing. * For men: Must be surgically sterile or compliant with a contraceptive regimen during and for 3 months after the treatment period Exclusion Criteria: * Patients with primary CNS tumor or CNS tumor involvement * Patients with history and/or current evidence of endocrine alteration of calcium-phosphate homeostasis * History and/or current evidence of ectopic mineralization/ calcification including but not limited to the soft tissue, kidneys, intestine, myocard and lung with the exception of calcified lymphnodes and asymptomatic coronary calcification * Current evidence of corneal disorder/ keratopathy incl. but not limited to bullous/ band keratopathy, corneal abrasion, inflammation/ulceration, keratoconjunctivitis etc., confirmed by ophthalmologic examination. * History or current evidence of cardiac arrhythmia and/or conduction abnormality * Women who are pregnant or nursing. Other protocol…