Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases

Inclusion Criteria: * Fetus with known enzymatic and, if possible, mutation diagnosis of selected lysosomal storage diseases, and history of enzymatic or mutation diagnosis of a previously affected family member. * Krabbe disease * Infantile metachromatic leukodystrophy disease (MLD) * Tay Sachs or Sandhoff (GM2 gangliosidoses) disease * Pelizaeus-Merzbacher disease (PMD). * Both parents have the "at risk" genotype * Both parents agree to psychological counseling prior to CVS * Both parents agree to delivery of subject at Duke University * Gestational age of \< 9 weeks by sure menstrual dating or ultrasound of a natural pregnancy. * Singleton fetus * No evidence of abnormal nuchal thickening on preliminary ultrasound prior to chorion villus biopsy Exclusion Criteria: * Pregnancy by in vitro fertilization * Evidence of a nuchal translucency of \> 3.0 mm at the time of the ultrasound for the chorion villus biopsy. * HIV, hepatitis C or hepatitis B positive maternal status * Active infection in the mother at the time of scheduled CVS or cell injection as determined by clinical practice