Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis

Inclusion Criteria: * Males or females age 18-70 * The active arm (Arm #1) includes randomly selected 100-125 charts of patients with a primary diagnosis of major depression and a CGI-S of ≥4 who began Deplin and SSRI or SNRI therapy at the same time beginning in January 2007 to the present; and, Control group (Arm #2) includes randomly selected 125-150 charts of patients with a primary diagnosis of major depression who began SSRI or SNRI therapy matched in severity (CGI-S of ≥4) Exclusion Criteria: * Folic acid \>400 mcg taken at any time during the study * Psychotic features in the current episode or a history of psychotic features * Any bipolar disorder (current or past) or any psychotic disorder (current or past) * Current or past treatment with vagus nerve stimulation, ECT, or transcranial magnetic stimulation * Antipsychotic therapy in conjunction with their antidepressant currently or in past 4 weeks