This phase II trial is studying how well giving belinostat together with carboplatin works in treating patients with recurrent or persistent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer that did not respond to carboplatin or cisplatin. Belinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving belinostat together with carboplatin may kill more tumor cells.
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Objective Response by Response Evaluation Criteria in Solid Tumors (RECIST) Criteria (Version 1.1)
Timeframe: From study entry, up to 5 years
Frequency and Severity of Observed Adverse Effects Graded According to NCI CTCAE Version 3.0
Timeframe: Every cycle during treatment and 30 days after the end of treatment
Progression Free Survival at 6 Months
Timeframe: Every other cycle for 6 months