CompletedNot Applicable

A Multi-Center Group to Study Acute Liver Failure in Children

United States158 participantsStarted 2000-01

Plain-language summary

The PALF study group began with 20 sites and now continues with 12 sites (11 in the United States and 1 in Canada) in the new funding period. The primary objective of the Pediatric Acute Liver Failure (PALF) study is to collect, maintain, analyze, and report clinical, epidemiological, and outcome data in children with ALF, including information derived from biospecimens.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Written informed consent/assent * Birth through 17 years of age * Biochemical evidence of acute liver injury * Coagulopathy not corrected by vitamin K (or other intervention intended to correct coagulopathy) * The presence of encephalopathy (ENC) is required if the INR is at least 1.5 and less than 2.0 * If INR is at least 2.0, the presence of ENC is not required Exclusion Criteria: * Known chronic underlying liver disease * Multi-organ system failure following heart surgery or ECMO * Solid organ or bone marrow transplantation * Acute trauma * Previously enrolled in the PALF Cohort Study * Other severe illness, condition, or other reason in the opinion of the investigator that would make the patient unsuitable for the study

Trial details

NCT IDNCT00986648

SponsorUniversity of Pittsburgh

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-12

View on ClinicalTrials.gov More Acute Liver Failure trials