Naloxone SR Capsules in Patients With Opioid Induced Constipation

Inclusion Criteria: * All subjects must give written informed consent * Male or female subjects greater than 18 years of age * Taking opioid full agonist therapy(oral or transdermal) for persistent non-cancer pain, for at least 4 weeks prior to baseline visit * Subjects with at least a 3 week history of OIC prior to baseline; where bowel dysfunction is predominantly due to opioids and started following commencement of opioid therapy * Subjects with \<3 SBMs a week and experiencing one or more bowel symptoms (incomplete evacuation, straining, hard/small pellets) for 25% or more of bowel movements during the screening period * Subjects must be willing to discontinue all current laxative (constipation) therapy. Bisacodyl will be provided and taken as required Exclusion Criteria: * Women of childbearing potential, unless surgically sterile or using adequate contraception (either IUD, oral or depot contraceptive, or barrier plus spermicide). Women using oral contraception must have started using it at least 2 months prior to enrolment * Women who are pregnant or breastfeeding * Symptoms suggestive of non-opioid related bowel dysfunction (e.g. IBS - intermittent constipation or diarrhoea) or have diarrhoea or loose stools in the 4 weeks prior to baseline * History of chronic constipation prior to commencing opioid therapy * Gastrointestinal disorders known to affect bowel transit, or contribute to bowel dysfunction (other than OIC) * Chronic faecal incontinence * Subjects who ha…