Prophylactic Treatment of Travellers' Diarrhoea With Rifaximin

Inclusion Criteria: * Adults ≥ 18 and \< 65 years * Good general condition (according to history and clinical examination) * Written informed consent * No pregnancy * No breast feeding * Efficacious contraception (e.g. oral, double-barrier) during the study and 4 weeks after termination of the study * No participation in other clinical trials 4 weeks before, during participation, and 4 weeks after participation in this study * Planned travel period between 6 and 28 days * Planned travel to South- and Southeast Asia * Planned time to arrival in South- or Southeast Asia ≤ 24 hours Exclusion Criteria: * Pregnancy * Breast feeding * Age \< 18 and ≥ 65 years * No written informed consent * Chronic gastrointestinal disease and/ or immune insufficiency * Low general condition (according to history and clinical examination) * Regular medication with gastrointestinal side-effects and/or immunosuppressive medication * Participation in other clinical trials 4 weeks before, during and 4 weeks after termination of the study * No efficacious contraception * Planned travel period \< 6 and \> 28 days * Planned travel outside South- and Southeast Asia * Vaccination against cholera using DUKORAL within 12 months prior to inclusion * Planned time to arrival in South- or Southeast Asia \> 24 hours * Known hypersensitivity against rifaximin or rifamycin-derivatives in general * Known lactose intolerance