Safety and Efficacy of an H1N1 Influenza Vaccine in People With Asthma

Inclusion Criteria: * Diagnosis of mild/moderate or severe asthma according to Severe Asthma Research Project (SARP) definitions and either a SARP participant or having prior participation in the studies or clinics of the investigators * Males and females age 12 (inclusive) and older * Females of child-bearing potential must not be pregnant and must agree to practice adequate contraception that may include, but is not limited to: abstinence, monogamous relationship with vasectomized partner, barrier methods such as condoms, diaphragms, spermicides, intrauterine devices, and licensed hormonal methods during the study for at least 30 days following the last vaccination. * Able to understand and comply with planned study procedures * Will provide written informed consent and assent (if age appropriate) prior to initiation of any study procedures Exclusion Criteria: * Allergy to eggs or other components of the vaccine, including gelatin, formaldehyde, octoxinol, thimerosal, and chicken protein * Positive urine pregnancy test within 24 hours prior to vaccination, if a female of childbearing potential * Currently breastfeeding * History of smoking 20 pack-years or greater (current or former smokers with a history of less than 20 pack-years can be included in the study) * Has been previously diagnosed by a physician with chronic obstructive pulmonary disease, chronic bronchitis, emphysema, or cystic fibrosis * Has received anticancer chemotherapy or radiation therapy (cytotoxic) …