Safety, Tolerability and Efficacy Study With a Fixed-Dose Combination (FDC) Ketoprofen Plus Omeprazole

Inclusion criteria: * Adults suffering from chronic inflammatory conditions, in particular, rheumatoid polyarthritis, ankylosing spondylitis (or related syndromes, such as, Reiters syndrome, psoriatic arthritis,) with a previous history or who are at risk of developing NSAID associated benign gastric ulcers, duodenal ulcers and gastroduodenal erosions in whom continued treatment with NSAIDs is necessary. * Presenting at the inclusion visit an acute episode of recent onset (\<48 hours) defined by average pain within the last 24 hours \>=50 mm on the Visual Analogue Scale (VAS). Exclusion criteria: * Hypersensitivity to ketoprofen or to omeprazole or to another proton-pump inhibitor or to any of the excipients. * Last trimester of pregnancy. * History of asthma induced by administration of ketoprofen or similar acting substances, such as other non-steroidal anti-inflammatory agents (NSAIDs) or acetylsalicylic acid. * Gastrointestinal disorder or surgery leading to impaired drug absorption. * Evidence of uncontrolled, or unstable cardio- or cerebrovascular disorder, which in the investigator's opinion would endanger a subject if they were to participate in the study. * Serious blood coagulation disorder including use of systemic anticoagulants. * Positive test result for H. pylori at screening. * Recent endoscopy showing any gastric or duodenal ulcer at least 3 mm in diameter with depth. * Severe hepatic failure. * Severe renal failure. * Severe heart failure. * Patients with…