CompletedPhase 4

Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding

South Korea1,034 participantsStarted 2006-09

Plain-language summary

This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.

Who can participate

Age range

16 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * liver cirrhosis * age between 16 and 75 years * Patients who have upper GI bleeding symptoms (hematemesis or melena) within 24 hours before enrollment * Patients whose systolic blood pressure \<100 mmHg or pulse rate \>100/min at the enrollment * Patients who were not performed endoscopic or pharmacologic therapy for varices * Signed informed consent Exclusion Criteria: * Pregnancy * Positive anti-HIV Ab * A history of severe side-effects or contraindications to study drugs * Severe cardiovascular diseases: acute myocardial infarction, A-V block, congestive heart failure, ischemic heart disease, hypertension (systolic blood pressure \>170 mmHg or diastolic pressure \>100 mmHg) * Chronic renal failure * Hepatocellular carcinoma with protal vein thrombosis * Coexisting malignancy except hepatocellular carcinoma

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

5-day Treatment Failure (Failure to Control Bleeding, Rebleeding, or Death)

Timeframe: 5 days after enrollment

Trial details

NCT IDNCT00966355

SponsorKorea University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2010-05

Results submitted2013-04-23

View on ClinicalTrials.gov More Variceal Bleeding, Cirrhosis trials

Who can participate

Age range

16 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.