A Comparative Post-marketing Study of Commercially Available Peripheral Nerve Gap Repair Options

Inclusion Criteria: * Require primary or secondary nerve injury repair with Hollow Nerve Conduit or AVANCE™ in at least 1 digital nerve; * Undergo End to End nerve to nerve graft coaptation on both the proximal and distal portion of the nerve gap in the AVANCE™ group or nerve entubulation in the Hollow Nerve Conduit group; * Be willing to comply with all aspects of the treatment and evaluation schedule over a 12 Month duration; and * Sign and date an IRB-approved written informed consent prior to initiation of any study procedures, including screening procedures. Exclusion Criteria: * Nerve gaps of \< 5 mm or \> 20 mm; * Estimated distance of regeneration of \>125 mm (distance from injury site to sensory target) * Nerve crush or avulsion injuries; * Incomplete nerve transections; * Injury requiring replantation of target digit; * Contralateral digital injuries corresponding to the target digit; * Nerve injuries in the affected limb proximal to the crease of the wrist; * End to side nerve repair; * Injuries with significant vascular damage which may impair adequate perfusion of the target limb; * Subjects who are undergoing treatment with chemotherapy, radiation therapy, or other know treatment which affects the growth of neural and/or vascular system; * Use of bovine collagen based hollow nerve conduit in a subject with known or suspected bovine sensitivity; * Subjects age ≤18 years or ≥70 years; * History neuropathy, diabetic or any other known neuropathy; * Secondary ner…