Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function (NCT00947479) | Clinical Trial Compass
UnknownNot Applicable
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Poland50 participantsStarted 2009-02
Plain-language summary
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide. OSA is a well established risk factor for systemic hypertension myocardial infarction or stroke and it has been documented that blood pressure rises in a very consistent fashion during apneic episodes. The incidence of the episodes of apnea during sleep causes repeated subclinical acute kidney injuries (AKI) contributing to the development of CKD. One of the mechanisms responsible for AKI might be endothelial injury followed by an increase of central aortic pressure.
Who can participate
Age range18 Years – 70 Years
SexMALE
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Inclusion criteria
✓. Males with high risk of obstructive sleep apnea syndrome as clinically assessed by coincidence of typical symptoms (e.g. daily somnolence, witnessed apnea, non-refreshing sleep), obesity and high score on Epworth sleepiness scale (ESS) with age range from 18 to 70 years