Preparing for Adolescent HIV Vaccine Trials in South Africa:

Inclusion Criteria: * Youth age 12-17 years * For 12-15 year olds - no sexual risk criteria * For 16-17 year olds (the age of lawful consent to sex in South Africa): sexually active (ever had sexual intercourse) * Willing to participate in HIV testing and counseling * Willing and able to assent to study * Parent or legal guardian willing to provide written consent * HIV-negative serostatus at screening and enrolment * Females must have a negative pregnancy test at screening/enrolment * Females must not be breastfeeding * Additional inclusion criteria for those accepting HPV vaccination: * No HPV immunizations * Females should agree to avoid pregnancy through to the end of the study and to take contraceptives throughout the study (access provided) Exclusion Criteria: * Exclusion criteria for those accepting HPV vaccination: * Presence of any serious illness requiring treatment with systemic medications, excluding short course oral steroids or inhaled steroid treatment for asthma * Contra-indication to vaccination, such as bleeding disorder * Previous allergic reaction to any vaccines or to constituents of these vaccines (yeast, thimerosal or aluminum) * Current immunomodulator therapy * Receipt of immunosuppressor therapy (more than 10mg/day of prednisone or equivalent for \>1 week) in the 6 months preceding enrollment date * Receipt of any vaccine within two weeks preceding enrollment date