Safety and Immunogenicity of Live Influenza A Vaccine for Avian Influenza H7N7

Inclusion Criteria: * Able to provide informed consent * General good health, without significant medical illness, physical examination findings, or significant laboratory abnormalities as determined by the investigator * Available for the duration of the trial * Female participants must agree to use effective birth control methods for the duration of the study. More information on this criterion can be found in the study protocol. * Agrees to store blood specimens for future research Exclusion Criteria: * Pregnancy or breast-feeding * Evidence of clinically significant neurologic, cardiac, pulmonary, hepatic, rheumatologic, autoimmune, or renal disease by history, physical examination, and/or laboratory studies including urine testing. Clinically significant ALT levels, as determined by the Principal Investigator, will be exclusionary at baseline, prior to vaccination. * Behavioral or cognitive impairment or psychiatric disease that in the opinion of the investigator affects the ability of the participant to understand and cooperate with the study protocol * Previous enrollment in an H7 influenza vaccine trial or in any study of an avian influenza vaccine * Seropositive to the H7N7 influenza A virus (serum HI titer greater than 1:8) * Positive urine drug toxicology test indicating narcotic use or dependency * Have medical, occupational, or family problems as a result of alcohol or illicit drug use during the past 12 months * Other condition that in the opinion of the inve…