A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers

Inclusion Criteria: * healthy volunteer between the ages of 18-55 * if a woman, must be of non childbearing potential (ie, post menopausal or surgically sterile) and have a negative pregnancy test * body mass index between 18-30 * body weight greater than or equal to 50 kilograms * blood pressure between 90 and 140 mgHg systolic and no higher than 90 mgHg diastolic * nonsmoker Exclusion Criteria: * History of or current clinically significant medical illness * clinically significant abnormal laboratory value(s) * clinically significant abnormal physical examination, vital signs or electrocardiogram * pregnant, lactating or completed last term pregnancy within six months of screening * use of any prescription or non prescription medication except for paracetamol (acetaminophen/TYLENOL), bisphosphonates (drugs to treat osteoporosis), hormone replacement therapy within 14 days of first dose of study medication * history of drug or alcohol abuse * history of smoking or use of nicotine-containing substances within the previous two months