Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency

Inclusion Criteria: * Previously diagnosed (e.g. more than 6 months ago) primary adrenal insufficiency with a stable daily glucocorticoid substitution dose for at least 3 months prior to study entry * Signed informed consent to participate in the study. Exclusion Criteria: * Clinical or laboratory signs of significant cerebral, cardiovascular, respiratory, Hepatobiliary, pancreatic disease * Clinically significant renal dysfunction * Clinical or laboratory signs of significant gastrointestinal emptying or motility disease * Any medication with agents which could interfere with hydrocortisone kinetics * Pregnant or lactating women * Regular dehydroepiandrosterone (DHEA) medication for the past 4 weeks * Oral oestrogen medication for the past 4 weeks * Deranged mineralocorticoid status