Inhaled GM-CSF Therapy of Autoimmune PAP

Inclusion Criteria: * Female of male 18 years of age or older * Diagnosis of autoimmune PAP * Able and willing to provide written informed consent * Eligible for whole lung lavage determined as the presence of persistent or progressive respiratory failure (PaO2 at rest \< 60 mm Hg) or desaturation \< 90% or \> 5 percentage points during standard exercise Exclusion Criteria: * Diagnosis with secondary PAP, congenital PAP, or hereditary PAP * Contraindication to whole lung lavage * Contraindication to administration of inhaled GM-CSF * Chronic lung disease associated with already existing respiratory failure, such as emphysema or pulmonary fibrosis, chronic heart failure, ischemic heart disease, active pulmonary embolism, progressive cancer, and other severe metabolic conditions