An Open-label, Randomized, Prospective Study of the Effectiveness, Safety, and Clinical Outcomes of Stapled Anastomoses Versus Hand-Sutured Anastomoses in Patients Undergoing Gastrointestinal End to End or Side to Side Anastomoses

Inclusion Criteria:a. * Able to comprehend and sign or, if illiterate, leave their thumb impression on the study informed consent document * 18 years to 75 years (inclusive) * Admitted on an emergency or elective basis requiring a single gastrointestinal anastomosis * Willing to adhere to standard postoperative care, including ventilator support if required * Female subject is postmenopausal (for at least 2 years) or surgically incapable of child bearing (at least 3 months post-surgical sterilization, with appropriate documentation) * If female subject is capable of child bearing, must use an acceptable method of birth control (hormonal or IUD) for at least 3 months prior to surgery and continue use throughout the study; maintained normal menstrual pattern for the past three months and has a negative urine pregnancy test prior to day of surgical procedure * Absence of medical history of psychiatric disorders that could limit the subject's ability to understand the procedure, comply with medical, surgical, and/or behavioral recommendations. Exclusion Criteria: * Women of childbearing potential who are pregnant at the time of screening or at the time of surgery * Subject is on treatment with Corticosteroid maintenance therapy (equivalent to \> 10mg/day of Prednisone), immunosuppressive or chemotherapeutic agents within 14 days prior to enrollment; or likely to receive one of these drugs during study period * Subject has connective tissue disease, renal failure necessitating …