Navelbine And Radiotherapy in Locally Advanced Lung Cancer

Inclusion Criteria: * Age ≥18 years * Patients with histologically or cytologically documented diagnosis of locally advanced NSCLC stage IIB to IIIB without pleural effusion * Performance status 0-1 on the ECOG scale * Weight loss ≤10% during the last 6 months * Adequate lung function measured as FEV1 ≥1.0 * Neutrophile count ≥1.5 x 109/L and platelet count ≥100 x 109/L * Serum bilirubin ≤1.5 upper limit of normal (ULN) * ALAT ≤2 x ULN * Able to comply with study and follow-up procedures * Patients with reproductive potential must use effective contraception * Written (signed) informed consent to participate in the study Exclusion Criteria: * Any unstable systemic disease (including active infection, unstable angina, congestive heart failure, severe hepatic, renal, or metabolic disease) * Any other active malignancies within 5 years (except for adequately treated carcinoma in situ of the cervix or basal or squamous cell skin cancer) * Prior chemotherapy for lung cancer, including neo- and adjuvant chemotherapy * Inability to take oral medication, or requirement of intravenous alimentation * Active peptic ulcer disease * Nursing mothers